Shigeo Kure Selected Research

Maternal Phenylketonuria

1/2021	Guide for diagnosis and treatment of hyperphenylalaninemia.
10/2018	Successful control of maternal phenylketonuria by tetrahydrobiopterin.

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Shigeo Kure Research Topics

Disease

15	Seizures (Absence Seizure) 02/2022 - 08/2007
11	Nonketotic Hyperglycinemia 01/2012 - 07/2002
7	Brain Diseases (Brain Disorder) 03/2021 - 01/2014
6	Hypertension (High Blood Pressure) 01/2022 - 10/2013
6	Neoplasms (Cancer) 12/2021 - 01/2015
6	Infantile Spasms (West Syndrome) 08/2017 - 07/2009
5	Infections 05/2022 - 12/2012
5	Adult-onset citrullinemia type 2 03/2022 - 04/2012
5	Intellectual Disability (Idiocy) 03/2021 - 04/2015
4	Galactosemias (Galactosemia) 01/2022 - 01/2019
4	Inflammation (Inflammations) 01/2022 - 03/2016
4	Spasm (Spasms) 05/2021 - 07/2009
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 01/2015
3	Hemorrhage 04/2022 - 05/2014
3	Cataract (Cataracts) 01/2022 - 11/2018
3	Leigh Disease (Leigh's Disease) 12/2021 - 03/2016
3	Hypoglycemia (Reactive Hypoglycemia) 01/2020 - 07/2012
3	Diarrhea 01/2020 - 01/2012
3	Myoclonic Epilepsies (Myoclonic Encephalopathy) 11/2018 - 09/2008
3	Leukemia 01/2017 - 01/2005
3	Hyperplasia 10/2015 - 03/2014
3	Cleft Palate (Palate, Cleft) 05/2008 - 01/2002
2	Atopic Dermatitis (Atopic Eczema) 01/2022 - 01/2020
2	Diabetes Mellitus 01/2022 - 07/2012
2	Obesity 01/2022 - 01/2021
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2021 - 01/2015
2	Leukoencephalopathies 12/2021 - 07/2006
2	Disease Progression 03/2021 - 10/2015
2	Osteogenesis Imperfecta (Lobstein Disease) 01/2021 - 05/2018
2	Phenylketonurias (Phenylketonuria) 01/2021 - 09/2004
2	Maternal Phenylketonuria 01/2021 - 10/2018
2	Tremor (Tremors) 01/2021 - 06/2013
2	Medium chain acyl CoA dehydrogenase deficiency 12/2020 - 08/2003
2	Proteinuria 12/2020 - 01/2019
2	Brain Injuries (Brain Injury) 11/2020 - 01/2019
2	Tuberous Sclerosis (Bourneville's Disease) 10/2020 - 11/2016
2	Brain Neoplasms (Brain Tumor) 10/2020 - 01/2016
2	Cysts 06/2020 - 01/2016
2	Astrocytoma (Pilocytic Astrocytoma) 06/2020 - 01/2016
2	Fibrosis (Cirrhosis) 01/2020 - 10/2017
2	Human Influenza (Influenza) 01/2020 - 02/2015
2	Eczema 01/2020 - 12/2019
2	Dyskinesias (Dyskinesia) 05/2019 - 04/2012
2	Body Weight (Weight, Body) 01/2019 - 11/2008
2	Hypersensitivity (Allergy) 10/2018 - 01/2018
2	Glioma (Gliomas) 04/2018 - 06/2014
2	Atrophy 06/2017 - 03/2015
2	Epilepsy (Aura) 04/2017 - 05/2016
2	Propionic Acidemia 01/2017 - 04/2004
2	Vomiting 12/2016 - 11/2014

Drug/Important Bio-Agent (IBA)

10	EnzymesIBA 01/2022 - 06/2004
9	Proteins (Proteins, Gene)FDA Link 05/2022 - 02/2003
9	Glycine (Aminoacetic Acid)FDA LinkGeneric 05/2018 - 11/2002
8	Pharmaceutical PreparationsIBA 01/2020 - 08/2004
7	DNA (Deoxyribonucleic Acid)IBA 10/2016 - 07/2004
7	glycine cleavage systemIBA 04/2012 - 07/2002
5	ORALIT (ORS)IBA 01/2022 - 12/2019
5	Valproic Acid (Depakote)FDA LinkGeneric 05/2021 - 01/2012
4	Galactose (Galactopyranose)FDA LinkGeneric 03/2022 - 01/2019
4	PotassiumIBA 01/2022 - 07/2012
4	SodiumIBA 01/2022 - 11/2014
4	sapropterin (tetrahydrobiopterin)FDA Link 01/2021 - 09/2004
4	Adenosine Triphosphate (ATP)IBA 06/2017 - 07/2012
4	Adrenocorticotropic Hormone (ACTH)FDA Link 04/2015 - 07/2009
4	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 09/2010 - 02/2006
3	Phenylalanine (L-Phenylalanine)FDA Link 03/2022 - 09/2004
3	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 07/2012
3	4- (2,4- difluorophenyl)- 2- (1H- indol- 3- yl)- 4- oxobutanoic acidIBA 06/2017 - 01/2015
3	Mitochondrial DNA (mtDNA)IBA 01/2016 - 12/2011
3	Anticonvulsants (Antiepileptic Drugs)IBA 04/2015 - 01/2014
3	Ketamine FDA LinkGeneric 09/2010 - 07/2004
2	Messenger RNA (mRNA)IBA 05/2022 - 01/2015
2	CitrullineIBA 03/2022 - 03/2021
2	CreatinineIBA 03/2022 - 10/2017
2	Triglycerides (Triacylglycerol)IBA 03/2022 - 03/2021
2	Methionine (L-Methionine)FDA Link 03/2022 - 01/2005
2	AllergensIBA 01/2022 - 01/2020
2	Amino Acids FDA Link 03/2021 - 07/2007
2	LipopolysaccharidesIBA 01/2021 - 12/2020
2	Phenylalanine Hydroxylase (Phenylalanine 4 Monooxygenase)IBA 01/2021 - 09/2004
2	CollagenIBA 01/2020 - 11/2016
2	Carnitine (L-Carnitine)FDA LinkGeneric 01/2020 - 06/2017
2	Myelin-Oligodendrocyte GlycoproteinIBA 10/2019 - 10/2015
2	Mitogen-Activated Protein KinasesIBA 05/2019 - 05/2007
2	Glutamine (L-Glutamine)FDA Link 10/2018 - 01/2014
2	Serine (L-Serine)FDA Link 05/2018 - 03/2010
2	Temozolomide (Temodar)FDA LinkGeneric 04/2018 - 01/2016
2	NucleotidesIBA 01/2018 - 01/2005
2	Collagen Type IV (Type IV Collagen)IBA 04/2017 - 11/2016
2	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2017 - 02/2015
2	Insulin (Novolin)FDA Link 12/2016 - 07/2012
2	aspartate-glutamate carrierIBA 12/2016 - 09/2015
2	citrinIBA 12/2016 - 09/2015
2	Protein Isoforms (Isoforms)IBA 12/2016 - 09/2015

Therapy/Procedure

16	Therapeutics 03/2021 - 07/2009
5	Ligation 10/2015 - 09/2010
4	Drug Therapy (Chemotherapy) 01/2022 - 01/2016
3	Transplantation 01/2017 - 01/2012
2	Euthanasia (Mercy Killing) 04/2022 - 01/2019
2	Radiotherapy 06/2020 - 04/2018